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Tapentadol is a prescription opioid medication used to relieve moderate to severe pain. It is sold under various brand names, such as Nucynta and Palexia. Tapentadol acts as both an opioid agonist, which means it binds to opioid receptors in the brain, and as a norepinephrine reuptake inhibitor, which affects the reuptake of certain neurotransmitters involved in pain modulation.
Tapentadol is commonly prescribed for the treatment of acute pain, such as postoperative pain, as well as chronic pain conditions like neuropathic pain associated with diabetic peripheral neuropathy. It provides pain relief by reducing the perception of pain and altering the way the brain responds to pain signals.

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