Master of Science with Bioinformatics
June 2012 - April 2014
Bachelor of Science with Bioinformatics
Sardar Patel University
Influenza Drug Resistance Database
Influenza viruses are responsible for acute respiratory illnesses during winter seasons in temperate climates. Epidemic influenza occurs due to small changes in surface glycoproteins, a process known as antigenic drift. Large changes in those proteins, known as antigenic shift, are responsible for larger pandemic influenza outbreaks. Seasonal influenza is expected annually, but the threat of pandemic influenza due to the large change in seasonal strains or introduction of novel strain requires the infection preventionist to have surveillance, infection
prevention interventions, and emergency preparedness plans in place. Several antiviral drugs are available for treatment of influenza, but vaccination is the primary control strategy. Each year, vaccines are modified to reflect the strains most likely to be circulating (Babcock H et al., 2009).
It is very important to understand the evolution of drug resistance strain. The analyses of the neuraminidase protein become vital for exploration of this issue. For that here we are concentrating on the neuraminidase protein. We developed neuraminidase protein sequence database which is specific to subtype H1N1. The database facilitates one to analyze the occurrence of drug resistance and compensatory mutations in protein sequences with respect to region, time duration and host of the virus isolation.