Achilonu - Synthesis Expert - Bloemfontein, Free State, South Africa

Matthew Achilonu

Bloemfontein, Free State, South Africa


Dr Achilonu’s doctoral research dealt with flavonoid modifications which resulted in development of novel methodologies to synthesize biologically active procyanidins and biflavonoids. Interestingly, the doctoral research work produced the following reminiscent outputs: the first oxidative formation of the inter-flavanyl bond in procyanidins which was published in a high impact factor journal (Organic Letters); a full USA patent (US 8, 501, 970 B2) and another USA Patent Application Publication, Pub. No.: US 2012/0289715 A1. During the research period, Dr Achilonu contributed to the synthesis of internal standards (radio-pharmaceuticals) that won the prestigious National Science and Technology Forum (NSTF) award for innovation in 2008. His postdoctoral work at University of the Free State involved photolytically modifying HIV/AIDS drugs – to discover more of their bioactivities. He took part in developing methodology for the synthesis of array of therapeutic C-glycoside compounds (aspalathin and derivatives), which produced a patent registration and an article. He also successfully developed a scalable process for the synthesis of novel 4β→8-catechin flavan-3-one procyanidin derivative – a precursor to a rare natural bioactive free phenolic procyanidin B-3 (an antioxidant).
Current research interests of Dr Achilonu include amongst others:
1. Designing and developing synthetic method(s) for preparation of novel organic compounds. Synthetic modification of bioactive natur


Synthesis Expert

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