Borriello - Medicinal Chemist - Como, Lombardy, Italy

Manuela Borriello

Como, Lombardy, Italy

Services

Medicinal Chemist

  • Full time
  • Part time
  • One time
  • Contract
  • Temp

Work History

Team Leader

Medicinal Chemistry Department

ROTTAPHARM, Monza (MI)
• Programme Team Leader for Lead Optimisation Programme for the treatment of Neuropathic pain
• Programme Team Leader for Lead Optimisation Programme for the treatment of Rheumatoid Arthritis coordinating the progression of potential candidates through other matrix functions (e.g. Pharmacology, DMPK and Toxicology) up to identification of a high quality candidate for Clinical Development.
• External collaboration outsourcing

Senior Research Scientist

Medicinal Chemistry Department

ROTTAPHARM, Monza (MI)
• Programme Team Leader for Early Lead Optimisation Programme for Osteoarthritis/Rheumatoid Arthritis
• Management of a medicinal chemistry group in the identification, design and synthesis of novel candidates to be use as DMOADs in the treatment of Osteoarthritis
• Supervision and coordination of a group of junior scientists in the synthesis of novel centrally active candidates for Sleep Disorders.
• Coordinating the progression of drug candidates in collaboration with other matrix functions (e.g. Biology, Toxicology and DMPK)
• Collecting, analysing and archiving biological and pharmacological study results.
• Coordinating the "Health and Safety Group" for Medicinal Chemistry Department.

Senior Research Scientist

Medicinal Chemistry Department

GLAXOSMITHKLINE - Neuroscience Drug Discovery, Verona
• Identification, design and synthesis of novel centrally active candidates for Sleep Disorders, depression and Anxiety (targeting 3 different disease mechanisms), Centrally Mediated Sexual Dysfunction and Schizophrenia.
• Coordinating the progression of drug candidates in collaboration with other matrix functions (e.g. Biology, Toxicology and DMPK)
• Collecting, analysing and archiving biological and pharmacological study results.
• Coordinated two different external research collaborations with Ferrara and Modena University.
• Chemistry Representative for Early Lead Optimisation Programmes for Depression and Anxiety and Drug Dependence.
• Supervision and coordination of a group of 3 junior scientists.
• Initiating patenting process including prior art searches, drafting patent applications in collaboration with internal patent attorney in order to set up valuable patent strategies.
• Preparing detailed monthly reports and writing manuscripts for publications.

Research Scientist

Medicinal Chemistry Department

GLAXOSMITHKLINE - Antibacterial then Psychiatry Drug Discovery, Verona
• Design and synthesis of novel active antimicrobials and centrally active drug candidates for Sleep Disorders via multi step organic synthesis and parallel synthesis.
• Provide quality experimental input to aid the drafting of patents and detailed monthly reports.

Junior Research Scientist

GLAXOWELLCOME R&D Centre

• Synthesis of active potential candidates for the Male Erectile Dysfunction via multi step organic synthesis, combinatorial and parallel synthesis.
• Supervised two summer students.

Graduate Student

Chemical Science Department

UNIVERSITA' DEGLI STUDI DI CAMERINO, Camerino
• Established Structure and Activity Relationship (SAR) of a new series of chromone molecules active at the α1 adrenoreceptors.

Qualifications & Certifications

Università degli Studi di Milano

Universita' degli Studi di Camerino

Liceo Ginnasio Statale

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