Upadhye - Fermentation - Mumbai, MH, India

Manohar Upadhye

Mumbai, MH, India

Services

Fermentation

Summary:

Monitoring and control of upstream production of fermentation cycle at Pilot Plant and Production plant level through PLC, SCADA and DCS.
Hands on experience of Bacterial and Fungal Fermentation from 20L to 160 KL.
Having good Exposure in downstream operation and in process laboratory analysis of fermenter broth.
Scale up and process parameter setup of new product batches from pilot level to production level.
Having capability to run, trouble shooting and process control of small scale to big scale Fermentation Plant.
Documentation as per Regulatory affair, USFDA and cGMP norms.
Exposure to commissioning of upstream Fermentation Facility

Work History

Assit. GM

Praj Industries, pune

From September 2011

PRAJ INDUSTRIES LIMITED, Pune (Maharashtra), Praj is acknowledged as a leading Indian multinational company with reference over 450 plant spread across 55 countries. Offering cutting edge, innovative processes and system including waste water treatment for alcohol, bio-diesel and brewery with after sales technical audit, demonstration run and technical support.

Job Responsibilities :

 Production of various liquid blend and solid formulation for yield improvement, contamination control and maximum product recovery for alcohol and brewery industry, production of Probiotic for animal feed
 Part of technical team to solve Clients Problem
 Handling Fermentation, solid ,liquid formulation Plant and downstream equipment through SCADA, PLC
 Production planning and dispatch activity as per customer requirement.
 Trouble shooting, Contamination control, process validation in fermentation.
 Scale up of new product (probiotic) batches from pilot level to production level.
 Cost control and standardization of the production media, process parameter with reduction in utility cost, Easy Operation at plant level. and productivity improvement

ACHIVEMENT

 Successful commission of New Fermentation, solid and liquid formulation facility at Jejuri site in given time period and standardization of process parameter; scale up of new technology from Pilot Plant to commercial level.
 Received Paris award for successful scale up of Praj Biotech Product.

Manager Fermentation

Dholka Ahmedabad (Gujarat)

February 2010 - August 2011

India's fastest growing biotech company with fermentation based multi product at same location. Having state-of-art Fermentation plant and manufacturing facility with USFDA accreditation.

Job Responsibilities:
➢ Upstream Production of Lovastatin, Pravastatin, Vancomycin, Cyclosporine, MPA, Tacrolimus, Sirolimus
➢ Handling Six Fermentation Plant and 21 production fermenter of 20 KL capacity through SCADA, PLC
➢ Production planning and achieve production target set by management
➢ Raw material planning, Monthly Report, daily MIS
➢ Man Power administration, control and interaction with service department to get the job done on timely basis.
➢ Trouble shooting, Contamination control, process validation in fermentation.
➢ Documentation as per USFDA and cGMP norms. Exposure to handle Vendor, EUGMP, WHO, USFDA and local audit.
➢ Scale up of new product batches from pilot level to production level.
➢ Cost control and standardization of the production media, process parameter with reduction in utility cost, Easy Operation at plant level. and productivity improvement


ACHIVEMENT
➢ Successful commission of New Fermentation facility at same location in given time period and standardization of process parameter; scale up of new technology from Pilot Plant to commercial level.
➢ Contamination control and improvement in productivity.
➢ Reduction in raw material consumption, Utility consumption , fermenter batch cycle and improvement in Activity
➢ Exposure given to work in R&D and Successful scale up of shake flask technology to Pilot plant level for Teicoplanin and Lipstatin.
➢ Joined as a Manager fermentation for new facility and now looking towards overall fermentation Plant

PREVIOUS JOB:

Manager (Pilot Plant) Fermentation

Fermentation

October 2006 - February 2010

diversified group having turn over above 18000 carore. Entered in fermentation business by utilizing state-of-art Fermentation
Plant facility at Matar, Baroda. Started production of CO-enzyme Q-10 with bacterial
Fermentation and Daunomycin other product like Lovastatin and H Acid under development
Stage at Pilot Scale. One of the largest manufacturers of gelatin in India

Job Responsibilities:
➢ Testing of culture for productivity improvement, reproducibility and viability of technology, Scale up of new product batches from pilot level to production level.
➢ Preparation of protocol, Design Experiment for Pilot Plant trial batches.
➢ Cost control experiment with respect to Raw material balancing, reduction in utility cost, process parameter optimization and For Easy Operation at plant level.
➢ Planning and conducting the process development experiments in association with Micro lab, P D Lab, R&D at Pilot Plant level.
➢ Man Power administration, control, trouble shooting, Contamination control, process validation in fermentation.
➢ Assigning work to Shift Executive (Shift in charge) and Supervision of all plant activities.
➢ Handling Fermenter from 10L to 150L capacity through PLC, SCADA and Scale up batches at fermentation plant from 200L to 160KL through DCS.

ACHIVEMENT
➢ Stabilization and standardization of process parameter; scale up of new technology from Pilot Plant to commercial level.
➢ Contamination control and improvement in productivity.
➢ Reduction in raw material consumption, Utility consumption , fermenter batch cycle and improvement in Activity
➢ Continuous utilization of pilot facility for experiment work, supporting activity for fermentation plant and culture testing for micro lab.
➢ Successful scale up of shake flask technology to pilot plant level and scale up to production level for Coenzyme Q10 and oncology products.


PREVIOUS JOB:

Executive fermentation

GLENMARK PHARMACEUTICALSLTD

From December 2004

One of the fastest growing Parma. Company with turn over above 450 carore. Manufacturing facility having USFDA approval at same location for different product.

Job Responsibilities:
➢ New product development, testing of productivity and viability of technology, plant feasibility and cost economics for the new product.
➢ Constant batch analysis and trouble shooting in fermentation.
➢ Planning, controlling and manpower administration.
➢ Scale up of new product batches from pilot level to production level.
➢ Cost control and standardization of the production media, process parameter, and productivity improvement.
➢ Microbiology lab, upstream and Down stream operation.
➢ Coasting for utility, raw material, and product material balancing for the job work carried at different location.
➢ Trial batches, Production batches, Job Work and process standardisation Experiment carried out with material indent to final dispatch at. Hi tech Biolab, Poona (Maharashtra), TGBL, Baroda, (Gujarat), Concord Biotech. Dholka, Ahmadabad (Gujarat)


PREVIOUS JOB:

Senior Officer (Shift In charge), Fermentation

Fermentation

July 1994 - December 2004

Fortune 15 Indian Pharmaceutical co. World's second largest manufacturer of Rifampicin and Lovastatin as second product. Having state-of-art Fermentation plant with manufacturing facility having with USFDA accreditation.

Job Responsibilities:
➢ Upstream Production of Rifamycin B, Lovastatin and Compactin
➢ Handling fermenters up to 90 KL capacity through DCS.
➢ Preparation and sterile transfer of Nutrient feed to main fermenters.
➢ Documentation as per USFDA and cGMP norms. Exposure to handle WHO, USFDA and local audit.
➢ Assigning work to Shift Officers and Supervision of all plant activities with strict compliance of cGMP and SOP. Monitoring and Control of process parameter in association with R&D department for Experimental batches at Pilot Plant level.
➢ Man Power administration and interaction with service department to get the job done on time.
➢ Trouble shooting in fermentation.
➢ Data, trend analysis and batch to batch data comparasition.
➢ Worked as a department TPM coordinator.
➢ Knowledge of SAP.
➢ Knowledge of raw material indent, inventory control, material balancing.
➢ In- process analysis of fermenter broth sample.
➢ Work as a member of contamination control task force
➢ Work as a Department Safety coordinator and won GM Shield for 2 times


PREVIOUS JOB:

Production Supervisor

Famy Care LTD

October 1993 - June 1994

Chakan, .Poona, India's largest manufacturers of copper "T"

Job Responsibilities:
Autoclaving, completion of production target in sterile area up to final stage, production planning, daily production report preparation, manpower handling of more than 60 workers in shift.

Projects

1) Production of Biofertiliser utilizing fatty alcohol industry effluent byAzotobacter paspali.

post graduate level project work

Qualifications & Certifications

Industrial Microbiology

North Maharashtra University

Microbiology

Poona University

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