Ahmadi - Microbiologist - Vancouver, BC, Canada

Malahat Ahmadi

Vancouver, BC, Canada

Services

Microbiologist

Work History

Associate Professor

Veterinary Medicine Faculty, University

Assistant Professor

Veterinary Medicine Faculty, University

Teaching Bacteriology courses for DVM , Master and PhD students.
Advising the microbiology projects.

fetus in sheep" under the supervision of Professor G. C. Mead

Surgery, Royal Veterinary College, London University

September 1998 - March 1999

(September 1998 to March 1999),
I was involved in a research project "Investigation the pathogenesis of Campylobacter fetus
fetus in sheep" under the supervision of Professor G. C. Mead.

Ph.D THESIS
(University of Tehran, University of London)

"The isolation of Campylobacter fetus fetus from Iran and the evaluation of humoral
immunity of wild and mutant strains of bacteria in sheep."

The first part of this study was undertaken at the Faculty of Veterinary Medicine, Tehran
University under the guidance of Professor H. Tadjbakhsh, emeritus Professor of Microbiology and Immunology and the second part of this study was undertaken at the Royal Veterinary
College, London University under the guidance of Professor G. C. Mead


BACKGROUND
Campylobacter fetus fetus is an important pathogen of humans and animals. In man it causes
systemic infections, enteritis in immunocompromised and abortion, it also causes abortion in cattle, sheep and goat.
Because the treatment is not so effective in animals, most countries attempt to produce an effective vaccine against Campylobacter fetus fetus in sheep.


HYPOTHESIS & OBJECTIVES
Modern vaccine development requires the identification of different subunit vaccines. The
role of S-Layer proteins of bacteria as an suitable antigenic candidate in vaccines against ovine abortion is important. The humoral immunity of wild (strain 23D) and mutant strains
(strains 6002, 6004, 501, 502) of Campylobacter fetus fetus in sheep estimated.
The techniques which were used in the study include:- 1) Isolation of bacteria.
2) Preparation of infective dose of bacteria.
3) Experimental infection.
4) Indirect ELISA.
5) SDS- Immunoblotting.


RESULTS
9
Results indicated that strain 23D with 97 KD protein as surface protein, has an important role in humoral immunity but there is direct evidence that 23D strain has an important role in the pathogenesis, therefore it cannot be a suitable candidate to produce a vaccine.

Humoral immunity caused by strain...

Resident of microbiology

Veterinary Medicine Faculty, University

Associate Professor in Microbiology

Lecturer

Veterinary Medicine Faculty, University

Qualifications & Certifications

Veterinary Medicine Faculty

Tehran University

Veterinary Medicine Faculty

Tehran University

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