Chigweshe - Chemist - Harare, Zimbabwe

Lorencia Chigweshe

Harare, Zimbabwe




Expert in the study of matter and its properties. Have experience working in both academic and pharmaceutical industry settings.

Work History

Research Associate

Adnexus Therapeutics, Boston, USA

August 2012 - January 2013

• Manage projects
• Develop, validate methods/flow charts of potential therapeutic targets according to company SOP
• Develop and run Enzyme Linked Immunosorbent Assay (ELISA) to study protein-protein interaction on potential therapeutic drug targets
• Run Surface Plasmon Resonance (SPR) experiments to study protein-protein interaction in support of drug discovery efforts
• Checking water quality before running assays
• Recording of experiments and data analysis in LIMS
• Perform maintenance of all SPR instruments to ensure smooth running of all laboratory experiments
• Analysis of process validation, identify deficiencies and develop improvement plans
• Execute experiments in accordance to proper laboratory procedure and in compliance with government regulations
• Sampling experimental instruments and testing developed methods
• Proposed automation of the ELISA result reporting system upon arrival and was key in seeing to the success of this upgrade

Laboratory Technician

Massachusetts General Hospital, Boston USA

July 2011 - July 2012

• Experimental data collection and analysis
• Conducted tests analyzed results on biological activities of the innate immune system, specifically looking at Mannose Binding Lectin (MBL). Examples include:
o Performed ELISA on biological and clinical samples and analyzed the optical density using JMP software
o Genotyped lab mice using Polymerize Chain Reaction (PCR)
o Maintained updated laboratory mice log, weaned and tagged mice
o Performed cardiac puncture of euthanized mice, collected, stored and managed serum samples
• Prepared and reviewed lab reports to properly document all laboratory results
• Designed, tested and modified experiments
• Improved existing experimental protocols
• Kept the laboratory pantry stocked to ensure efficient running of all experiments
• Presented experimental progress to laboratory members consisting of physician scientists and medical professors on a monthly bases
• Maintained a working budget for laboratory supplies

Laboratory Technician

University of Massachusetts, USA

May 2010 - September 2010

• The Explored efficiency of FlAsH and F2FlAsH fluorescent dyes using Fluorescent Correlation Spectroscopy (FCS)
• Created recombinant DNA in Staph. Aureus, purify expressed protein using affinity chromatography and used gel electrophoresis to identify protein bands
• Maintained up-to-date and accurate records of all laboratory experiments
• Presented research findings at the University of Massachusetts Amherst Summer Undergraduate Research Symposium

Laboratory Assistant

Purdue University, USA

May 2009 - August 2009

• Grew Na0.5Bi0.5TiO3 piezoelectric thin films on SrTiO3 substrate by hydrothermal growth method
• Characterized film structure and pieozoelectric properties of Na0.5Bi0.5TiO3 using Electron Microscopy (EM), Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and X-Ray Diffraction (XRD)

Technology Consultant

Mount Holyoke College, USA

January 2008 - December 2011

• Greet and welcome library patrons
• Answer patrons’ questions and assist them with technology needs
• Scan and upload academic documents to the college electronic learning site to students and faculty access
• Train new staff
• Manage other students and organize their work shifts

Undergraduate Researcher

Mount Holyoke College, USA

January 2008 - December 2010

• Preparation of written reports and presentation of reports to other staff members
• Review and proofread reports and scientific publications
• Investigated the proton conduction pathways in Yttrium doped SrZrO3 and BaZrO3 perovskites using the Vienna ab initio simulation package implementation of density functional theory
• Training of new staff
• Wrote vertex and color coding programs used to enumerate all simple N-step periodic proton conduction paths in SrZrO3 and BaZrO3 perovskites
• Prepared lab reports and presented research findings at the Mount Holyoke College’s annual Learning Through Application (LEAP) Symposium



pH Meter, Analytical Balance, Spectrophotometer, AFM, SEM, NMR, HPLC, GC, Mass Spectrometry, Thermometer, Refractive Index, Conductivity Meter, XRD, Beckman Coulter Liquid Handlers, Automatic Plate Washers and Stacker, Centrifuge, FCS, SPR, Personal Computers


Co-authored the following scientific papers:
• Mannose-binding lectin binds to amyloid β protein and modulates inflammation. M. Larvie, T. Shoup, W-C. Chang, L. Chigweshe, K.L. Hartshorn, M. R. White, G. Stahl, D. Elmaleh, and K. Takahashi. J. Biomed. Biotechnol.2012:929803: 2012

• The effect of dopant at the Zr site on the proton conduction pathways of SrZrO3: An orthorhombic perovskite. M.A. Gomez, M. Chunduru, L. Chigweshe, and K.M. Fletcher. J. Chem. Phys. 132(21): 2010

• The effect of Y dopant on the proton conduction pathways of BaZrO3, a cubic perovskite. M.A. Gomez, M. Chunduru, L. Chigweshe, L. Foster, S. J. Fensin, K.M. Fletcher, and L.E. Fernandez. J. Chem. Phys. 132(21): 2010

Qualifications & Certifications


Mount Holyoke College, USA

Hippo Valley High School

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