Katchar - Research Scientist - Somerville, Massachusetts, USA

Kia Katchar

Somerville, Massachusetts, USA

Services

Research Scientist

Summary:

Assay development research scientist with more than ten years of experience at leading academic institutions, pharmaceutical, biotech and consulting companies. Extensive scientific knowledge and experience in vitro and in vivo assays, with an emphasis on T , B cell and NK cell immune responses in mucosal immunology, pulmonary and intestinal inflammatory , infectious and autoimmunity diseases. Demonstrated ability in assay design, optimization, development and validation. Recognized ability in people management, education, publication and writing SOP.
-Proven record of high quality publications in peer-reviewed journals .
-Excellent communication skills, with the ability to interface with both technical and layperson audiences
Areas of Expertise: Immune-cells phenotyping and regulation, cytokine profiling ,inflammatory disease, Biomarkers, Flow cytometry, T cell immunology.

Work History

Vertex Pharmaceutical

August 2012 - November 2013

• Designed, developed and implemented assays for detection target biomarker.
• Designed and developed flow cytometry-based assays to characterize freshly isolated primary CD34+ stem cells and T lymphocytes.
• Developed translational based approaches to differentiate research projects within immune and inflammatory diseases.
• Designed and executed innovative experiments in the areas of cell biology, flow cytometry and multiplex analysis of soluble inflammatory mediators.
• Independently prepared and communicated technical reports, publications and oral presentations.
• Delivered updates to senior level management in context of overall project goals.
• Kept up to date of relevant literature and develop visibility outside of functional area.
• Assumed responsibility for direct reports as needed including recruiting, managing, mentoring and developing scientific staff.

Senior scientist on the main project in adaptation of HCV/HIV

KIR-associated Immune

pressures; resulted in published Abstract and presentation at Keystone Symposia Colorado 2012.
• Managed database and phylogenetic analysis of HCV related immune response.
• Led projects on NK cells phenotyping and receptor interactions.

Staff Scientist

Ragon Institute

July 2011 - July 2011

RESEARCH STAFF SCIENTIST

Ragon Institute

July 2011 - August 2012

Instructor in Medicine

Reumatology,Mass General Hospital

October 2009 - July 2011

Phenotypical and functional and receptor interaction studies of NK cells and NKT cells in Lyme Arthritis and Rheumatoid Arthritis

Instructor in Medicine/ Assistant in Immunology

Massachusetts General Hospital

October 2009 - June 2011

Investigating the function and phenotype of natural killer cells and NKT cells in Rheumatoid arthritis and Lyme arthritis.

INSTRUCTOR IN MEDICINE

Division of Allergy and Immunology, Rheumatology, MGH

October 2009 - July 2011

Led and conducted multiple experiment in studying immune cells function in
Lyme Arthritis and Rheumatoid Arthritis resulted in 2 published papers.
• Supported postdocs and assisted in design and executing the experiments.
• Participated in weekly planning of scientific seminars and meetings.
• Assisted in general day to day laboratory routines.

Research Post doctoral fellow

Beth Israel Deaconess Medical Center

September 2004 - April 2009

Investigating the humoral immunresponse to Clostridium Difficile associated diarrehea, establishing a model for investigation for immuneresponse to recurrent infection

Research Fellow

Harvard Medical School

September 2004 - January 2009

to Clostridium difficile Toxins A and B in patients with Clostridium difficile associated diarrhea.
Investigated the phenotype and function of T regulatory cells in intestinal inflammatory diseases.
Developed a novel experimental animal model to study C. difficile associated disease, immune response and recurrence.
Studied T cell mediated immune responses in murine inflammatory models.
Studied immune responses to recombinant protein vaccines in animal models.

POSTDOCTORAL RESEARCH FELLOW

Beth Israel Deaconess Medical Center Harvard Medical School

September 2004 - August 2009

• Investigated cell-mediated immune responses to Clostridium difficile Toxins A and B in patients with Clostridium difficile associated diarrhea.
• Characterized the phenotype and function of T regulatory cells in intestinal inflammatory diseases (IBD).
• Investigated T cell pathways in IBD animal models.
• Developed a novel experimental animal model to study C. difficile associated disease, immune response and recurrence.
• Studied T cell mediated immune responses in murine inflammatory models and conducted assays to study immune responses to recombinant protein vaccines in animal models.
• Studied immune cells interaction and activation in IBS.

PhD graduate

Karolinska Institutet

January 1999 - August 2004

Studying Immune cells in respiratory inflammatory disorder/diseases. Activation, phenotype and function.

Doctoral Research

Karolinska Institute

January 1999 - August 2004

Investigated the role of specific T cell subsets and NK cells in patients with pulmonary inflammation.
Studied the role of inflammatory mediators, chemokine and cytokine receptors in brochoalveolar lavage and peripheral blood cells in patients' with asthma, Sarcoidosis, COPD and in healthy individuals.

Karolinska Institute

January 1999 - August 2004

Sweden

• Investigated the role of specific T cell subsets and NK cells in patients with pulmonary inflammation including Sarcoidosis, Asthma and COPD.
• Executed experiments to identify inflammatory mediators, chemokine and cytokine receptors in brochoalveolar lavage and peripheral blood cells in patients and healthy individuals by utilizing Flow cytometric assays.
• Dissertation Thesis: T lymphocyte and NK cell function in pulmonary inflammation in sarcoidosis

Research

Karolinska Institute

August 1997 - January 1999

Analysis of T cell receptor variable genes in patients with Amyotrophic Lateral Sclerosis (ALS) in relation to the disease.

Karolinska Institute

August 1997 - January 1999

, Stockholm, Sweden
• Investigated T cell receptor variable genes in patients with Amyotrophic Lateral Sclerosis (ALS) in relation to the disease resulted in 1 published paper.
• Conducted database patient screenings and questioner for the study

SCIENTIST

Sangtec Medical Biotech/ Microbiology

April 1992 - August 1997

consulting laboratory, Bromma, Sweden
• Conducted Quality control for medical devise, Clinical diagnostic assays.
• Measured environmental analysis, air quality, clean room facilities, microbiology and fungi analysis.
• Managed and expedited approval of product release for Pharma and technical institutes.
• Assisted in documentation of regulatory submissions according to ISO 90000
• Worked according to GLP and GMP.
• Project management and regulatory related documents.

Qualifications & Certifications

Biomedical Science

Karolinska institutet

BSc

Karolinska Institute

Master

2003

Microbiology

Karolinska Institute

Biomedical Laboratory Science

Karolinska Institute

Immunology/Respiratory Medicine

Karolinska Institute

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